The EPoX 8RDA+ comes with sound built-into the motherboard that is quite good, certainly good enough that an add-on sound card is not needed. I'll be using an add on sound card, but if you're using the motherboard built-in sound then now is a good time to connect the speakers, even though you really won't hear anything until the motherboard chipset drivers are installed later. But if you will be using an add-on sound card then you can skip this page - instead a later page where I describe the installation of both the sound card and speakers will be of interest to you.
I'm using the Creative Cambridge SoundWorks PCWorks speakers. The wires on these speakers are nice and long so it's usually not difficult to place the speakers and volume control in the best location. Ideally, the speakers should be equidistant from the listener. The sub-woofer should be up against the wall, although it can't be flush since the wiring connects in the back. The next three pictures are color-coded to help show where each plug connects. Two things I'll point out. First, notice the volume control has two similar looking connectors coming out of it - the one that is gun shaped plugs into the sub-woofer and the one that is straight plugs into the I/O panel. Second, notice that each actual speaker wire ends in a bare split to be connected to red and black connectors - one wire in the split has a red band and this indicates to attach it to the red connector.
Connect the speakers to the Line Out connector on the I/O panel, circled in green below. There is etching next to each connector indicating what each is for, although it's difficult to make out even in the enlarged picture, and not very helpful even when it can be clearly seen.
Turn the speaker on - there's a power button on the back of the sub-woofer. Plug everything back into the rear of the computer, including the video cable, keyboard cable, mouse cable and power cord. Here's how the back of the case looks with all of these connections made.